Current Issues of Pharmacy and Medical Sciences

Influence of the dissolution medium type on the release of diclofenac sodium and papaverine hydrochloride from granules and ...

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 5-9

REGINA KASPEREK, MAGDALENA NALEŚNIAK, KAROL IWANIAK, EWA POLESZAK

Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.1/a.01

Abstract

Influence of the dissolution medium type on the release of diclofenac sodium and papaverine hydrochloride from granules and tablets
 
The release studies of diclofenac sodium (DIC) and papaverine hydrochloride (PAP) from composed granules and tablets into the dissolution media at different pH using the flow-through cell apparatus were carried out. The solubilities of these active substances vary and depend on the pH of a dissolution medium which confirmed the outcomes of the release studies on granules and tablets containing only one substance DIC or PAP. The most effective dissolution medium for the carried out release study of DIC and PAP from composed solid dosage form as granules or tablets was citrate buffer at pH 6.5.

Keywords

diclofenac sodium, papaverine hydrochloride, release study, dissolution media

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