Current Issues of Pharmacy and Medical Sciences

Influence of the dissolution medium type on the release of diclofenac sodium and papaverine hydrochloride from granules and ...

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 5-9


Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.1/a.01


Influence of the dissolution medium type on the release of diclofenac sodium and papaverine hydrochloride from granules and tablets
The release studies of diclofenac sodium (DIC) and papaverine hydrochloride (PAP) from composed granules and tablets into the dissolution media at different pH using the flow-through cell apparatus were carried out. The solubilities of these active substances vary and depend on the pH of a dissolution medium which confirmed the outcomes of the release studies on granules and tablets containing only one substance DIC or PAP. The most effective dissolution medium for the carried out release study of DIC and PAP from composed solid dosage form as granules or tablets was citrate buffer at pH 6.5.


diclofenac sodium, papaverine hydrochloride, release study, dissolution media


  1. Bartolomei M. et al.: Physicochemical characterization and intrinsic dissolution studies of a new hydrate form of diclofenac sodium: comparison with anhydrous form. J. Pharm. Biomed. Anal. 40, 1105, 2006.
  2. Bertocchi P. et al.: Diclofenac sodium multisource prolonged release tablets-a comparative study on the dissolution profiles. J. Pharm. Biomed. Anal. 37, 679, 2005.
  3. Bravo S.A., Lamas M.C., Salamon C.J.: In vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. J. Pharm. Pharm. Sci. 53, 213, 2002.
  4. Cetin M., Atila A., Kadioglu Y.: Formulation and in vitro characterization of Eudragit L100 and Eudragit L-100-PLGA nanoparticles containing diclofenac sodium. AAPS PharmSciTech. 11, 3, 1250, 2010.
  5. Gabr K.E.: Effect of organic acids on the release patterns of weakly basic drugs from inert sustained release matrix tablets. Eur. J. Pharm. Biopharm. 38, 199, 1992.
  6. Kasperek R.: Granulat na bazie diklofenaku sodowego i sposób jego wytwarzania. Polish Patent No P-364419, 2008.
  7. Kasperek R.: Simultaneous release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus described by dimensionless equations. Acta Pol. Pharm. Drug Res. 68, 2, 261, 2011.
  8. Kasperek R.: Tabletki na bazie diklofenaku sodowego o działaniu przeciwbólowym i spazmolitycznym oraz sposób ich wytwarzania. Polish Patent No P-380847, 2010.
  9. Kasperek R. et al: Development of spectrophotometric method for simultaneous estimation of diclofenac sodium and papaverine hydrochloride in tablets based on simultaneous equation method. Curr. Issues Pharm. Med. Sci. 25, 2, 182, 2012.
  10. Kincl M. et al.: Study of physicochemical parameters affecting the release of diclofenac sodium from lipophilic matrix tablets. Acta Chim. Slov. 51, 409, 2004.
  11. Kiortsis S. et al.: Drug release from tabletted wet granulations comprising cellulosic (HPMC or HPC) and hydrophobic component. Eur. J. Pharm. Biopharm. 59, 73, 2005.
  12. Lin S.Y., Lin K.H., Li M.J.: Micronized ethylcellulose used for designing a directly compressed time-controlled disintegration tablet. J. Controlled Release 70, 321, 2001.
  13. Martindale: The complete drug reference. (2011). The Pharmaceutical Press, London.
  14. Miyajima M. et al.: Factors influencing the diffusion-controlled release of papaverine from poly (L-lactic acid) matrix. J. Controlled Release 4, 56, 85, 1998.
  15. Moritz M., Łaniecki M.: Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study. J. Solid State Chem. 184, 1761, 2011.
  16. Mourăo S.C. et al.: Dissolution parameters for sodium diclofenac-containing hypromellose matrix tablet. Int. J. Pharm. 386, 201, 2010.
  17. Palomo M., Ballesteros M., Frutos P.: Analysis of diclofenac sodium derivatives. J. Pharm. Anal. 21, 83, 1999.
  18. Pharmindex. Vademecum leków. (2012). UBM Medica Poland, Warsaw.
  19. Podlewski J.K., Chwalibogowska-Podlewska A. (2010). Leki współczesnej terapii. The Press of Medical Tribune Poland, Warsaw.
  20. Polish Pharmacopoeia IX. (2011). Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, PTF Warsaw, Poland.
  21. Proikakis C.S., Tarantili P.A., Andreopoulos A.G.: The role of polymer/drug interactions on the sustained release from poly(DL-lactic acid) tablets. Eur. Polym. J. 42, 3269, 2006.
  22. Rani M., Mishra B.: Comparative in vitro and in vivo evaluation of matrix, osmotic matrix, and osmotic pump tablets for controlled delivery of diclofenac sodium. AAPS PharmSciTech. 5, 71, 1, 2004.
  23. Saleh S.I. et al.: Comparative dissolution profiles of five internationally-available sustained-release diclofenac dosage forms. S.T.P. Pharma. Sci. 2, 3, 242, 1992.
  24. Samani S.M., Montaseri H., Kazemi A.: The effect of polymer blends on release profiles of diclofenac sodium from matrices. Eur. J. Pharm. Biopharm. 55: 351, 2003.
  25. Savaşer A., Özkan Y., Işimer A.: Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. Farmaco 60, 171, 2005.
  26. Serajuddin A.T.M., Rosoff M.: pH-solubility profile of papaverine hydrochloride and its relationship to the dissolution rate of sustained-release pellets. J. Pharm. Sci. 73, 1203, 1984.
  27. Şanli O., Ay N., Işiklan N.: Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads. Eur. J. Pharm. Biopharm. 65, 204, 2007.
  28. The United States Pharmacopeia USP XXII. (1990). The United States Pharmacopeial Convention, Inc., Rockville, USA.
  29. Velasco M.V. et al: Influence of drug: Hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. J. Controlled Release 57, 75, 1999.



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