Current Issues of Pharmacy and Medical Sciences

Evaluation of serum adiponectin concentration in patients with type 2 diabetes

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 4, 15

ARLETA MALECHA-JĘDRASZEK1, HELENA DONICA1, BEATA MATUSZEK2,
BEATA WOJTYSIAK-DUMA
1, ANDRZEJ NOWAKOWSKI2

1 Department of Biochemistry Diagnostics, Medical University of Lublin, Poland

2 Department of Endocrinology, Medical University of Lublin, Poland

Abstract

Adiponectin, a recently discovered protein secreted exclusively and abundantly from adipose tissue, known as Acrp30 (adipocyte complement-related protein of 30kDa), AdipoQ, apM1 protein (adipose most abundant gene transcript-1), and GBP28 (gelatin-binding protein of 28kDa), comprises approximately 0.01% of the total plasma protein in healthy humans. Recent studies have suggested that circulating adiponectin is a bioactive protein with multivalent functions such as insulin sensitizing, anti-inflammatory, anti-atherogenic activities and also prevents endothelial dysfunction. Although its structure and source are known, the role and clinical implications of adiponectin have not been definitively established. The aim of this study was to evaluate serum adiponectin concentration in overweight and obese patients with type 2 diabetes, in comparison to healthy participants, and also assess the possible relationship of this cytokine with selected demographic, anthropometric and biochemical parameters. The study was conducted in 40 patients with diabetes type 2 with the average duration of the disease from diagnosis 9.4±8.1 years. Among the enrolled subjects were 17 women and 23 men with mean age 58.9±11.1 years. The control group was composed of 25 healthy subjects (11 women and 14 men) with the mean age of 55.3±7.1 years, with no disturbances in carbohydrate metabolism and with normal body mass. The mean adiponectin concentration in the study group was significantly lower compared to the control group. However, in the examined group the females had a significantly higher adiponectin level than males. We observed significant positive correlations between adiponectin concentration and age and level of HDL-cholesterol in the study group. Furthermore, significant negative correlations were found between adiponectin concentration and body mass, BMI, level of glucose, HbA1C, triglicerydes and activity of ALT, AST. In conclusion, we report that decreased adiponectin concentration in overweight and obese patients with type 2 diabetes in comparison to healthy subjects and the observed correlations of adiponectin with lipid metabolism parameters may suggest antiatherogenic effects of this protein.

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Keywords

adiponectin, adipose tissue, diabetes

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