Two-component biocomposite: chitosan – hydroxyapatite. Preparation and estimation of properties
Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 4, 14
JUSTYNA ZALEWSKA1, MATEUSZ PIĄTEK1,
GRAŻYNA GINALSKA1, ANNA WOJTASZ-PAJĄK2
Forming a biofilm on orthopedic implant surface is a serious problem nowadays. This research was focused on making new type of biocomposite with antimicrobial properties. Biocomposite was protected from bacterial adhesion (Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 25992) and biofilm formation. Biomaterial hybrid showed prolonged antimicrobial activity (25-41 days). HAp-chitosan-gentamicin granules were resistant to sterilization process and saved its antimicrobial activity. The possibility of forming different shapes from chitosan-modified HAp granules make this biocomposite promising for future medical applications.
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hydroxyapatite, chitosan, antibiotic immobilization, implant infection, gentamicin