Current Issues of Pharmacy and Medical Sciences

Two-component biocomposite: chitosan – hydroxyapatite. Preparation and estimation of properties

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 4, 14

JUSTYNA ZALEWSKA1, MATEUSZ PIĄTEK1,
GRAŻYNA GINALSKA1, ANNA WOJTASZ-PAJĄK2

Chair and Department of Biochemistry and Biotechnology, Medical University in Lublin, Poland
Department of Food and Enviromental Chemistry, National Marine Fisheries Research Institiute, Gdynia, Poland

Abstract

Forming a biofilm on orthopedic implant surface is a serious problem nowadays. This research was focused on making new type of biocomposite with antimicrobial properties. Biocomposite was protected from bacterial adhesion (Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 25992) and biofilm formation. Biomaterial hybrid showed prolonged antimicrobial activity (25-41 days). HAp-chitosan-gentamicin granules were resistant to sterilization process and saved its antimicrobial activity. The possibility of forming different shapes from chitosan-modified HAp granules make this biocomposite promising for future medical applications.

Files to download

Keywords

hydroxyapatite, chitosan, antibiotic immobilization, implant infection, gentamicin

Calendar

April 2021

Mon Tue Wed Thu Fri Sat Sun
      01 02 03 04
05 06 07 08 09 10 11
12 13 14 15 16 17 18
19 20 21 22 23 24 25
26 27 28 29 30