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May peripheral blood hemoglobin concentration be a prognostic factor among patients diagnosed with metastatic clear cell ...

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 4, 11

TOMASZ CISZEWSKI1, TOMASZ KUBIATOWSKI2, JUSTYNA SZUMIŁO3,
ELŻBIETA STAROSŁAWSKA4, KRZYSZTOF J. CZARNOCKI5,7, FRANCISZEK BURDAN6,8

1 Department of Chemotherapy, St John’s Cancer Center, Lublin, Poland

2 Department of Chemotherapy, St John’s Cancer Center, Lublin, Poland

Department of Clinical Pathomorphology, Medical University in Lublin, Lublin, Poland

4 Department of Chemotherapy, St John’s Cancer Center, Lublin, Poland

5 St John’s Cancer Center, Lublin, Poland

6 St John’s Cancer Center, Lublin, Poland

Occupational Hygiene and Ergonomic Dept., Lublin University of Technology, Lublin, Poland

8 Department of Human Anatomy, Medical University in Lublin, Lublin, Poland

Abstract

May peripheral blood hemoglobin concentration be a prognostic factor among patients diagnosed with metastatic clear cell renal carcinoma treated with targeted therapies?
 
Molecular targeted agents that are registered for the treatment of metastatic clear cell renal carcinoma significantly improved prognosis of patients with such diagnosis. Because the treatment costs are high, the problem of predicting the response to applied therapy and objective estimation of patient prognosis seems to be very important at present. The aim of the current study was the evaluation of peripheral blood hemoglobin concentration – parameter measured on different stages of treatment, as a prognostic factor. The analysis that was performed revealed that hemoglobin level may be useful in determining prognosis among patients diagnosed with metastatic clear cell renal carcinoma. Measurements performed before beginning of targeted therapy as well as after its termination seem to have prognostic value.

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Keywords

metastatic clear cell renal carcinoma, targeted therapies, anemia, prognostic factors

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