Current Issues of Pharmacy and Medical Sciences

Giant cell tumor of the maxilla - case report and long-term follow-up results

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 4, 8


Department of Oral and Maxillofacial Surgery, Department of Oral Surgery Medical University in Lublin, Poland


Giant cell tumor is a rare disease of the head and neck region. Predominantly giant cell tumor involves the end of long bones. Sometimes it occurs in the head and neck areas, predominantly in mandible and maxilla. The tumor arises from the nonosteogenic stromal cells of the bone marrow. Giant cell tumors are defined as either aggressive or nonaggressive lesions. An aggressive type tumor is large, rapidly growing, loose and displaced teeth. Nonaggressive type giant cell tumors do not exhibit these signs. Surgery is the most accepted treatment of giant cell tumor. Sometimes surgery can be performed in association with new approaches, in an attempt to avoid recurrence. Surgical treatment can be followed by local injection of steroids or antiangiogenic therapy using interferon alfa-2a.

We report a 17-year-old girl with a large, slowly growing giant cell tumor of the maxilla. The patient was treated with surgical excision.

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giant cell tumor, tumor gigantocellularis, surgical treatment


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