Current Issues of Pharmacy and Medical Sciences

Evaluation of the endoglin levels in maternal serum in preeclamptic pregnancies

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 3, 25

LASKOWSKA MARZENA, OLESZCZUK JAN

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Poland

Abstract

The objective of the study was to determine whether women with pregnancy complicated by preeclampsia have the different circulating levels of endoglin. The study was carried out on 41 preeclamptic patients (group PRE) and 41 healthy normotensive pregnant women without renal and cardiac diseases. The maternal serum endoglin concentrations were determined using a sandwich ELISA assay. There were no statistically significant differences in gravidity, parity, maternal age and height and BMI in patient profiles between groups. Maternal weight was lower in the control group of patients than in the group of preeclamptic patients. Systolic and diastolic blood pressure and mean arterial blood pressure were significantly higher in the study group of preeclamptic pregnant women than in the control group. Our study revealed the elevated levels of endoglin in serum of women with pregnancy complicated by preeclampsia. The mean values were 16.019 +/- 2.898ng/ml in preeclamptic patients and 10.963 +/- 4.0178ng/ml in the healthy controls.  Preeclampsia is associated with higher maternal circulating levels of endoglin than normal pregnancy. These findings suggest that endoglin share a common pathogenic pathway as preeclampsia.

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Keywords

Endoglin, pregnancy, preeclampsia, angiogenic factors

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