Current Issues of Pharmacy and Medical Sciences

Evaluation of selected biochemical parameters in the serum of rats pretreated with simvastatin, doxepin or their combination

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 3, 12

MARIOLA HERBET, MONIKA GAWROŃSKA-GRZYWACZ,
KRZYSZTOF KWIATEK, EWA JAGIEŁŁO-WÓJTOWICZ

Department of Toxicology, Medical University of Lublin, Lublin

Abstract

The aim of this study was to estimate the influence of 14-day simultaneous i.p. adminiatration of simvastatin and doxepin on  some biochemical parameters indicating liver function in rats. The activity of AST, ALT and the concentration of total protein and α-fetoprotein was determined. The results show that 14-day combined application with simvastatin and doxepin causes the increase of transaminases activities and AFP level but the decrease of total protein in comparison to the groups receiving these drugs individually. It seems that the combined treatment with simvastatin and doxepin is possible on the condition of the regular control of parameters indicating liver function. These data can be helpful in the treatment with these drugs.

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Keywords

simvastatin, doxepin, biochemical parameters

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