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Characterization of the anticonvulsant properties of the various p-isopropoxyphenylsuccinimide derivatives in the maximal ...

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 3, 9

MARTA ANDRES-MACH1, JAROGNIEW J. ŁUSZCZKI1,2

Isobolographic Analysis Laboratory, Institute of Agricultural Medicine, Lublin, Poland

Department of Pathophysiology, Medical University of Lublin, Lublin, Poland

Abstract

Characterization of the anticonvulsant properties of the various p-isopropoxyphenylsuccinimide derivatives in the maximal electroshock-induced seizure test in mice
 
The aim of the study was to examine whether some p-isopropoxyphenylsuccinimide derivatives display anticonvulsant properties in the mouse maximal electroshock seizure (MES) model. Fifteen p-isopropoxyphenylsuccinimide derivatives used in these studies were administered i.p. at a constant dose of 300 mg/kg at four pretreatment times: 15, 30, 60 and 120 min and mice were subjected to electroconvulsions by applying an alternating current (25 mA, 50 Hz, 500 V, 02 s of stimulus duration) via ear-clip electrodes. Three out of 15 p-isopropoxyphenylsuccinimide derivatives showed strong anticonvulsant properties against MES-induced seizures. The protection against maximal electroconvulsions was noticed for: N-(o-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide (o-CAMIPPS), N-(m-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide (m-CAMIPPS) and N-(p-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide (p-CAMIPPS). All compounds, except for m-CAMIPPS, showed the highest percentage of the anticonvulsant activity at 60 min after i.p. administration. Only m-CAMIPPS displayed the highest anticonvulsant activity at 15 min after its i.p. administration.

Anticonvulsant properties of the selected p-isopropoxyphenylsuccinimide derivatives indicate that these substances certainly are worthy of further and more detailed studies in other animal seizure models to determine their anticonvulsant profile in preclinical studies.

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Keywords

epilepsy, p-isopropoxyphenylsuccinimide derivatives, maximal electroshock-induced seizure test

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