Current Issues of Pharmacy and Medical Sciences

Methods of antibiotic bonding to vascular prostheses

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 3, 8

MONIKA OSIŃSKA-JAROSZUK1, GRAŻYNA GINALSKA2

Department of Biochemistry, M. Curie-Skłodowska University, Lublin

Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin

Abstract

Besides autogenous implantable materials, synthetic vascular prostheses made of synthetic polymeric biomaterials are frequently used in surgical vessel reconstructions. The important problems appearing while using these types of biomaterials are postoperative infections, which may repeatedly lead to limb amputation or even patient’s death. Presently, in order to avoid the postoperative infections, prostheses are soaked in an appropriate antibiotic solution to obtain weak adsorptive or ionic interactions. Moreover, new methods of antibiotic bonding to biomaterials by strong covalent immobilization are investigated. This work is a short review of the presently known methods of antibiotics bonding. 

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Keywords

vascular prostheses, antibiotics immobilization, antibacterial prostheses protection

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