Current Issues of Pharmacy and Medical Sciences

The automated hematology analyzers

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 3, 7

IWONA KAZNOWSKA-BYSTRYK

Chair and Department of Laboratory Diagnostics, Medical University of Lublin

Abstract

The complete blood count (CBC) and differential leukocyte count (DLC) are the backbone of any laboratory evaluation, not only used by general practitioners, but also by other medical specialties. The CBC and DLC are used to diagnose anemia, to identify acute and chronic illnesses, bleeding tendencies, and white blood cell disorders. During the last quarter century, blood cell analysis has progressed from the use of labor-intensive manual procedures to the use of highly automated instruments. Modern hematology analyzers provide new additional parameters enabling earlier and more precise diagnosis. Moreover, they incorporate flow cytometry, robotics and expert system technologies.

Sensitive flags now allow the identification of abnormal cells or spurious counts, but only the most sophisticated hematology analyzers have optimal flagging and more simple analyzers, especially those without a WBC differentiation scattergram, do not possess the same sensitivity for detecting anomalous results. Therefore it is crucial that obtained results are clear for clinicians, and the parameters obtained completely used. 

The study presents the current state of knowledge about hematology analyzer,  concerning principles of their operation, their advantages and limitations, as well as the provided parameters.

Files to download

Keywords

automated hematology analyzer, complete blood count, differential leukocyte count

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