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Influence of combined administration of Ukrain and tricyclic antidepressants on basic biochemical serum parameters of kidney ...

Annales UMCS, Sectio DDD, Pharmacia, Vol. XXIV, N 3, 2

MONIKA GAWROŃSKA-GRZYWACZ, MARIOLA HERBET,
JOANNA PAZIK, JUDYTA HAWRYLUK, EWA JAGIEŁŁO-WÓJTOWICZ

Department of Toxicology, Medical University of Lublin, Poland

Abstract

Influence of combined administration of Ukrain and tricyclic antidepressants on basic biochemical serum parameters of kidney function in rats

 

Our research was aimed to assess the impact of 10-day simultaneous dosing of Ukrain and tricyclic antidepressants, imipramine (IMI) and amitriptyline (AMI), on basic biochemical parameters of renal function in rats. The concentrations of creatinine, urea and β2-microglobulin were determined in animal serum. Based on the results of the study it was found that 10-day combined administration of Ukrain and IMI decreased creatinine concentration (Ukrain 28 mg/kg) and increased urea level (Ukrain 14mg/kg) in blood serum. The same combination of drugs did not affect the concentration of β2-microglobulin. However, the application of Ukrain and AMI for 10 days resulted in the decrease of creatinine and urea (Ukrain 28 mg/kg) concentrations in the serum of rats. The β2-microglobulin level increased in groups of rodents treated with Ukrain (14 and 28 mg/kg) and AMI compared with Ukrain and decreased in relation to AMI. These adverse fluctuations in the studied biochemical parameters in blood serum of rats may indicate a risk of renal impairment after combined 10-day administration of Ukrain and tricyclic antidepressants. We suppose our conclusions may be useful in clinical practice to avoid the above-mentioned adverse effect.

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Keywords

Ukrain, TCAs, nephrotoxicity, rats

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